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CAS RN: 20069-09-4 | Product Number: P2361
Piperlongumine
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Purity: >97.0%(HPLC)
Synonyms:
- 5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-trans-2-propenyl]-2(1H)-pyridinone
- (E)-1-[3-(3,4,5-Trimethoxyphenyl)acryloyl]-5,6-dihydropyridin-2(1H)-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
78,00 €
|
1 | 18 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P2361 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9NO__5 = 317.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20069-09-4 |
| Reaxys Registry Number | 1503970 |
| PubChem Substance ID | 354333528 |
| MDL Number | MFCD00075706 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 123.0 to 127.0 °C |
Properties (reference)
| Melting Point | 125 °C |
GHS
Related Laws:
| RTECS# | UU7785850 |
Transport Information:
| HS Number | 2933790090 |
Application
Piperlongumine: A Pyridone Alkaloid with Anti-Tumor Properties
Piperlongumine is a pyridone alkaloid isolated from Piper longum L. found in southern India and Southeast Asia. Recent reports have shown that piperlongumine have anti-tumor properties. Piperlongumine increases the level of reactive oxygen species (ROS) selectively in tumor cells, and induces apoptotic cell death in tumor cells but not normal cells.
References
- Selective killing of cancer cells by a small molecule targeting the stress response to ROS
- Piperlongumine induces autophagy by targeting p38 signaling
- Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells
- Overview of the therapeutic potential of piplartine (piperlongumine) (a review)
- Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death
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