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Published TCIMAIL newest issue No.198
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CAS RN: 157716-52-4 | Product Number: P2831
Perifosine
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Purity: >98.0%(HPLC)
Synonyms:
- 1,1-Dimethylpiperidin-1-ium-4-yl Octadecyl Phosphate
- 1,1-Dimethyl-4-piperidiniumyl Octadecyl Phosphate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€122.00
|
1 | 9 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2831 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__5__2NO__4P = 461.67 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 157716-52-4 |
| Reaxys Registry Number | 11186113 |
| PubChem Substance ID | 468592745 |
| MDL Number | MFCD00927554 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Melting point | 230.0 to 234.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 232 °C |
GHS
Related Laws:
| RTECS# | TN5910000 |
Transport Information:
| HS Number | 2933399099 |
Application
Perifosine: An Oral Akt Inhibitor
The PI3K/Akt/mTOR pathway is aberrantly active in most human cancer cells and contributes to cancer cell growth, proliferation, and survival. Perifosine, an alkyl phospholipid, is an oral Akt inhibitor that display potent anti-proliferative activity in human tumor models. Perifosine has been shown to target phosphatidylinositol 3-kinase (PI3K)/Akt signaling. (The product is for research purpose only.)
References
- Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation
- Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
- Perifosine: update on a novel Akt inhibitor (a review)
- Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity (a review)
- Current View on the Mechanism of Action of Perifosine in Cancer (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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