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Published TCIMAIL newest issue No.198
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CAS RN: 148553-50-8 | Product Number: P2840
Pregabalin
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Purity: >98.0%(T)
Synonyms:
- (S)-3-(Aminomethyl)-5-methylhexanoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€46.00
|
1 | ≥60 |
|
| 50MG |
€156.00
|
12 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2840 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__1__7NO__2 = 159.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 148553-50-8 |
| Reaxys Registry Number | 8404778 |
| PubChem Substance ID | 468592747 |
| MDL Number | MFCD00917044 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation | +10.0 to +12.0 deg (C=1, Water) |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | MO6452000 |
Transport Information:
| HS Number | 2922498590 |
Application
Pregabalin: A Potent Ligand for the α2δ Subunit of Voltage-Gated Ca2+ Channels in the Central Nervous System
Pregabalin is one of the analogs of γ-aminobutyric acid (GABA) [A0282], but it works as a potent ligand for the α2δ subunit of voltage-gated Ca2+ channels in the central nervous system that exhibits potent anxiolytic, analgesic, and anticonvulsant properties in a range of animal models. Pregabalin binds potently and selectively to the α2δ subunit of "hyper-excited" voltage-gated calcium channels (VGCCs). The binding of pregabalin to VGCCs changes their conformation, reducing Ca2+ influx at nerve terminals. Consequently, pregabalin modulates the release of excitatory neurotransmitters in "hyper-excited" neurons, restoring them to normal physiological state. This mechanism of action is believed to confer on pregabalin its anxiolytic, analgesic, and anticonvulsant properties. (The product is for research purpose only.)
References
- Identification of the α -δ-1 unit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
- Pharmacology and mechanism of action of pregabalin: The calcium channel α2-δ (alpha2-delta) subunit as a target for antiepileptic drug discovery (a review)
- Pregabalin: From molecule to medicine (a review)
- Simultaneous high-performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phtaldialdehyde and fluorescence detection
Product Documents (Note: Some products will not have analytical charts available.)
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