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CAS RN: 50-55-5 | Product Number: R0007

Reserpine


Purity: >98.0%(T)(HPLC)
Synonyms:
Documents:
1G
€68.00
4   ≥20 
5G
€192.00
1   ≥20 

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Product Number R0007
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__3__3H__4__0N__2O__9 = 608.69  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 50-55-5
Reaxys Registry Number 102015
PubChem Substance ID 87575589
SDBS (AIST Spectral DB) 10992
Merck Index (14) 8145
MDL Number

MFCD00005091

Specifications
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -172 to -182 deg(C=1, DMF)
Properties (reference)
Specific Rotation 177° (C=1,DMF)
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 200-047-9
RTECS# ZG0350000
Transport Information:
HS Number 2939790090
Application
Reserpine: A Central Nervous System Depressant and an Inhibitor of Multidrug Efflux Pumps in Bacteria

Reserpine is an alkaloid of rauwolfia sharing the yohimbine [Y0002] pentacyclic skeleton. Pharmacological studies have revealed that reserpine is a central nervous system depressant. Reserpine depletes stores of catecholamines (dopamine [A0305], noradrenaline [A0906] and adrenaline [A0173]) and 5-hydroxytryptamine [S0370] by inhibiting their accumulation in many organs, including the brain and adrenal medulla. The depression of the central nervous system results in a decreased heart rate and a lowering of arterial blood pressure.
In addition, some studies have reported that reserpine enhances the in vitro activity of fluoroquinolones, such as norfloxacin [N0817], ciprofloxacin [C2227, C2510] and sparfloxacin [S0840], against strains of Staphylococcus aureus expressing distinct efflux-related multidrug resistance pumps. (The product is for research purpose only.)

References


Application
Reagen for myalgia model
References

Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine

F. Ponzio, G. Achilli, G. Calderini, P. Ferretti, C. Perego, G. Toffano, S. Algeri, Neurobiol. Aging. 1984, 5, 101.

Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia

Y. Nagakura, T. Oe, T. Aoki, N. Matsuoka, Pain 2009, 146, 26.


Application
Reagent for pain model
References

Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia

Y. Nagakura, T. Oe, T. Aoki, N. Matsuoka, Pain 2009, 146, 26.


Application
Reagent for schizophrenia model
References

Electroconvulsive shock: sustained decrease in norepinephrine uptake affinity in a reserpine model of depression

E. D. Hendley, B. L. Welch, Life Sci. 1975, 16, 45.

Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression

H. J. Bein, Pharmakopsychiatry Neuropsychopharmakol. 1978, 11, 289.

Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association

L. L. Skalisz, V. Beijamini, S. L. Joca, M. A. Vital, C. Da Cunha, R. Andreatini, Prog. Neuropsychopharmacol. Biol. Psychiatry 2002, 26, 879.

Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine: Behavioral and Neurochemical Studies in the Rat

L. Antkiewicz-Michaluk, A. Wąsik, E. Możdżń, I. Romańska, J. Michaluk, Neurotox. Res. 2014, 26, 85.


PubMed Literature


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