text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 61413-54-5 | Product Number: R0110

Rolipram


Purity: >98.0%(HPLC)
Synonyms:
  • 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
Documents:
50MG
€87.00
8   ≥20 
250MG
€302.00
2   ≥20 

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number R0110
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__1NO__3 = 275.35  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Heat Sensitive
CAS RN 61413-54-5
Reaxys Registry Number 1588548
PubChem Substance ID 253659657
Merck Index (14) 8251
MDL Number

MFCD00270906

Specifications
Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 130.0 to 134.0 °C
Properties (reference)
Melting Point 132 °C
GHS
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 262-771-1
RTECS# UY5749237
Transport Information:
HS Number 2933790090
Application
Rolipram: A Selective PDE4 Inhibitor

Rolipram is a selective inhibitor of phosphodiesterases 4 (PDE4s) originally developed as an antidepressant agent in 1990s, but fell out of favor because of its undesirable gastrointestinal side effects. Nowadays, rolipram continues to be used in research as a PDE4 inhibitor. PDE4s are responsible for hydrolysis of the cyclic nucleotides cAMP [A2381] and cGMP to 5’-AMP [A0158] and 5’-GMP [G0338], particularly in nerve and immune cells. The inhibition of PDE4s by rolipram induces the elevation of intracellular cAMP concentration. Consequences rolipram-induced elevation of cAMP suppress expression of proinflammatory cytokines and other mediators of inflammation. Rolipram has been reported as a drug for the treatment of autoimmune diseases, Alzheimer's disease, cognitive enhancement, and respiratory diseases like asthma and COPD. Rolipram is a racemic compound, and (R)-rolipram [R0182] is more potent than (S)-rolipram [R0183] as a PDE4 inhibitor. (The product is for research purpose only.)

References


PubMed Literature


Documents
Safety Data Sheet (SDS) Search
Please select Language.

The requested SDS is not available.

• Please check that the Product Number you have entered is correct.

• If your information is correct and you are still not able to view the requested SDS,  please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number is entered
Other Documents

Life Science