Roxithromycin: An Acid-Stable and Enteric Absorbent Semi-Synthetic Macrolide Antibiotic
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Roxithromycin (abbrev: RXM) is chemically synthesized from erythromycin [
E0751] to create a more acid-stable antimicrobial and prevents the degradation of the erythromycin base to the hemiketal intermediate. RXM has an
in vitro antibacterial profile similar to that of erythromycin. RXM has a pharmacokinetic profile that is characterized by excellent enteric absorption within macrolide antibiotics achieving high concentrations in most tissues and body fluids. In addition, RXM immunomodulatory activities have reported.