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Published TCIMAIL newest issue No.198
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CAS RN: 144875-48-9 | Product Number: R0197
Resiquimod
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Purity: >98.0%(HPLC)
Synonyms:
- 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€59.00
|
2 | 1 |
|
| 100MG |
€194.00
|
4 | 25 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | R0197 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__2N__4O__2 = 314.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 144875-48-9 |
| Reaxys Registry Number | 9792901 |
| PubChem Substance ID | 354335079 |
| Merck Index (14) | 8151 |
| MDL Number | MFCD00937759 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 193 °C |
| Maximum Absorption Wavelength | 325 nm |
GHS
Related Laws:
| RTECS# | NJ5911320 |
Transport Information:
| HS Number | 2933998090 |
Application
Resiquimod: A Toll-Like Receptor Agonist
Resiquimod (R-848) is a tricyclic imidazoquinolone compound and an imiquimod [I0747] analog. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. Reportedly, resiquimod act as an immunomodulator and an anti-viral agent through activation immune cells via the Toll-like receptor 7 and 7/8 (TLR7 and TLR7/8) dependent signaling pathway. And then, resiquimod induces mRNA encoding cytokines including interferon-α (INF-α) at the treatment site. (The product is for research purpose only.)
References
- Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
- Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
- Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
- The antiviral activity of toll-like receptor 7 and 7/8 agonists (a review)
- The use of Toll-like receptor 7/8 agonists as vaccine adjuvants (a review)
PubMed Literature
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