Published TCIMAIL newest issue No.198
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CAS RN: | Product Number: R0274
Reagents for Condensation Reactions (EDCI·HCl, HOBt·H2O) (HPMC encapsulated)
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Purity:
Synonyms:
- EDCI·HCl ca. 0.25 mmol/capsule, HOBt·H2O ca. 0.04 mmol/capsule (HPMC encapsulated)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10EACH |
€100.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
Contents (per one capsule)
- EDCI·HCl : ca. 0.25 mmol
- HOBt Monohydrate : ca. 0.04 mmol
Directions for Use
- Each capsule contains all reagents for a single use on 0.20 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine. Typical condition: 0.20 mmol of carboxylic acid and 1.0 equiv of amine in water (0.2 M) at 30 °C.
Related Products
- D1601 EDCI·HCl
- H0468 HOBt Monohydrate
| Product Number | R0274 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
Specifications
| Appearance | White to Almost white capsule |
| Functionality test (conversion ratio) | min. 90.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H311 : Toxic in contact with skin. H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H373 : May cause damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. H410 : Very toxic to aquatic life with long lasting effects. H228 : Flammable solid. |
| Precautionary Statements | P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P391 : Collect spillage. |
Related Laws:
Transport Information:
| UN Number | UN2926 |
| Class | 4.1 / 6.1 |
| Packing Group | III |
| HS Number | 3822190090 |
Application
TCI Practical Example: The Condensation Reaction Using a Capsule Reagent
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Used Chemicals
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Procedure
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Reagents for condensation capsule (one capsule) was added to a solution of 4-bromobenzoic acid (40 mg, 0.20 mmol, 1.0 eq.), morpholine (17 μL, 0.20 mmol, 1.0 eq.) in H2O (1 mL) at r.t. and the mixture was stirred at 30 °C for 24 hours. The reaction solution was diluted with sat. Na2SO4 aq. (15 mL) and extracted with ethyl acetate (15 mL x 2), and the organic layer was washed with 2 mol/L HCl aq. (15 mL), sat. NaHCO3 aq. (15 mL) and brine (15 mL). The organic layer was dried over sodium sulfate, concentrated under reduced pressure, and the crude product was purified by silica gel chromatography (ethyl acetate:hexane = 2:1 - 1:1) to afford (4-bromophenyl)(morpholino)methanone (48 mg, 89% yield) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
The shape of the capsule is like below image and each capsule includes EDCI·HCl (ca. 0.25 mmol) and HOBt·H2O (ca. 0.04 mmol).
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
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Analytical Data
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(4-Bromophenyl)(morpholino)methanone
1H NMR (400 MHz, CDCl3); δ 7.57 (d, J = 8.4 Hz, 2H), 7.30 (d, J = 8.4 Hz, 2H), 3.74-3.44 (m, 8H).
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Lead Reference
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- Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
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Other Reference
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- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
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