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Published TCIMAIL newest issue No.198
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CAS RN: 1069-66-5 | Product Number: S0894
Sodium Valproate
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Purity: >98.0%(T)
Synonyms:
- Sodium 2-Propylpentanoate
- Valproic Acid Sodium Salt
- 2-Propylvaleric Acid Sodium Salt
- Sodium 2-Propylvalerate
- 2-Propylpentanoic Acid Sodium Salt
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€63.00
|
3 | 36 |
|
| 100G |
€187.00
|
1 | 32 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
[Handling Notes]
This product may extract droplets to the inner wall during storage, but no quality issue.
| Product Number | S0894 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__1__5NaO__2 = 166.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 1069-66-5 |
| Reaxys Registry Number | 4212221 |
| PubChem Substance ID | 172089122 |
| Merck Index (14) | 9913 |
| MDL Number | MFCD00078604 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Ion exchange titration) | min. 98.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 213-961-8 |
| RTECS# | YV7876000 |
Transport Information:
| HS Number | 2915907098 |
Application
Sodium Valproate: A GABA Enhancer and a HDAC Inhibitor
Valproic acid [P0823] and its sodium salt are one of the major antiepileptic agents. The mechanisms of action have not been established. However, it has been suggested that its activity in epilepsy is related to increased brain concentrations of γ-aminobutyric acid (GABA) [A0282] and dopamine [A0305] in brain.1,2) Furthermore, valproic acid and its sodium salt have recently been shown to inhibit histone deacetylases (HDACs) which play important roles in regulation of gene transcription and pathogenesis of cancer.3-5) (The product is for research purpose only.)
References
- 1)Effects of Sodium Dipropylacetate on γ-Aminobutyric Acid and Biogenic Amines in Rat Brain
- 2)Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action (a review)
- 3)Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
- 4)Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
- 5)Histone Deacetylase Inhibitors: Overview and Perspectives
- 6)Simple and sensitive fluorimetric liquid chromatography method for the determination of valproic acid in plasma
- 7)A high throughput and selective method for the estimation of valproic acid an antiepileptic drug in human plasma by tandem LC-MS/MS
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