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Published TCIMAIL newest issue No.198
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CAS RN: 515-03-7 | Product Number: S0916
Sclareol
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Purity: >96.0%(GC)
Synonyms:
- (1R,2R,8aS)-Decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€48.00
|
Contact Us | ≥80 |
|
| 5G |
€152.00
|
Contact Us | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0916 |
Purity / Analysis Method 
|
>96.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__0H__3__6O__2 = 308.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 515-03-7 |
| Reaxys Registry Number | 2054148 |
| PubChem Substance ID | 253660564 |
| MDL Number | MFCD00869558 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 96.0 % |
| Melting point | 99.0 to 103.0 °C |
| Specific rotation [a]20/D | -5.0 to -3.0 deg(C=1,CHCl3) |
Properties (reference)
| Melting Point | 101 °C |
| Boiling Point | 189 °C/3 mmHg |
| Specific Rotation | -4° (C=1,CHCl3) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
| EC Number | 208-194-0 |
| RTECS# | QK0301900 |
Transport Information:
| HS Number | 2906190090 |
Application
Sclareol: A Labdane-Type Diterpene with Cytotoxic Activity against Human Leukemic Cell Lines
Sclareol is a labdane-type diterpene, which is used as a fragrance. It has also demonstrated significant cytotoxic activity against human leukemic cell lines. Some bioactive compounds are synthesized from sclareol.
References
- Fragrance material review on sclareol
- Terpenoids from Salvia sclarea
- Labdane type diterpenes down-regulate the expression of c-myc protein, but not of bcl-2, in human leukemia T-cells undergoing apoptosis
- The effect of sclareol on growth and cell cycle progression of human leukemic cell lines
- Synthesis of Ambrox® from (-)-sclareol and (+)-cis-abienol
- First Enantiospecific Synthesis of the Antitumor Marine Sponge Metabolite (-)-15-Oxopuupehenol from (-)-Sclareo
- Direct resistively heated column gas chromatography (Ultrafast module-GC) for high-speed analysis of essential oils of differing complexities
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