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Published TCIMAIL newest issue No.201
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CAS RN: 38748-32-2 | Product Number: T2899
Triptolide
×
Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€232.00
|
3 | 15 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T2899 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4O__6 = 360.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 38748-32-2 |
| Reaxys Registry Number | 1692435 |
| PubChem Substance ID | 172089133 |
| Merck Index (14) | 9747 |
| MDL Number | MFCD00210565 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 228.0 to 235.0 °C |
| Specific rotation [a]20/D | -165.0 to -159.0 deg(C=0.15, MeOH) |
Properties (reference)
| Melting Point | 229 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | YK7751000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2932209090 |
Application
Triptolide: A Diterpene Triepoxide with Potent Immunemodulation, Anti-Inflammatory and Anti-Tumor Properties
Triptolide, a diterpene triepoxide, is a major compornent in the extract of Chinese herb Tripterygium wilfordii Hook F (TWHF). Triptolide reportedly has multiple pharmacological activities including anti-inflammatory, immunemodulation, antiproliferative and pro-apoptotic activity. Triptolide cannot only induce tumor cell apoptosis directly, but can also enhance apoptosis induced by cytotoxic agents by inhibiting NFκB activation. (The product is for research purpose only.)
References
- Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) (a review)
- Triptolide and its expanding multiple pharmacological functions (a review)
- Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms (a review)
- Triptolide: Progress on research in pharmacodynamics and toxicology (a review)
- Determination of triptolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reverse-phase high-performance liquid chromatography
- Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study
Application
Studies of the Drug Delivery of Triptolide
References
- Solid lipid nanoparticle and microemulsion for topical delivery of triptolide
- A study of microemulsion systems for transdermal delivery of triptolide
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