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Published TCIMAIL newest issue No.198
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CAS RN: 22345-47-7 | Product Number: T3509
Tofisopam
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
- 1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€71.00
|
3 | 15 |
|
| 250MG |
€229.00
|
1 | 4 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3509 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__6N__2O__4 = 382.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 22345-47-7 |
| Reaxys Registry Number | 629080 |
| PubChem Substance ID | 354334774 |
| Merck Index (14) | 9503 |
| MDL Number | MFCD00823171 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 7.00 to 7.70 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 157 °C |
| Maximum Absorption Wavelength | 310 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P391 : Collect spillage. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 244-922-3 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Tofisopam: A 2,3-Benzodiazepine Compound with the Regulation of Autonomic Function
Tofisopam is a 2,3-benzodiazepine compound which has an effect of the regulation of autonomic function. Unlike 1,4-benzodiazepines like diazepam and clonazepam, tofisopam has no sedative, hypnotic or anticonvulsant effects. It is reported that tofisopam bind to the omega subtype of the benzodiazepine receptors. (The product is for research purpose only.)
References
- Is tofisopam an atypical anxiolytic? (a review)
- Anxiolytic 2,3-benzodiazepines, their specific binding to the basal ganglia (a review)
- The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis
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