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CAS RN: 134308-13-7 | Product Number: T3856

Tolcapone


Purity: >98.0%(HPLC)
Synonyms:
  • 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
Documents:
50MG
€160.00
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200MG
€295.00
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Product Number T3856
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__4H__1__1NO__5 = 273.24  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 134308-13-7
Reaxys Registry Number 8151577
Merck Index (14) 9508
MDL Number

MFCD00866569

Specifications
Appearance White to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 142.0 to 146.0 °C
Properties (reference)
Melting Point 145 °C
GHS
Related Laws:
RTECS# PC4952500
Transport Information:
HS Number 2914790090
Application
Tolcapone: A Selective and Reversible Inhibitor of Catechol-O-methyltransferase (COMT)

Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT) which is one of several enzymes that degrade catecholamines (such as L-DOPA [D0600], dopamine [A0305], L-epinephrine [A0173], and norepinephrine [A0906]). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including catecholamines. Tolcapone crosses the blood-brain barrier and can inhibit both peripheral and central COMT activity. Therefore, it has been suggested that tolcapone prolong the biological half-life of L-DOPA and the therapeutic effect of L-DOPA for Parkinson's disease patients. (The product is for research purpose only.)

References


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