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CAS RN: 55297-96-6 | Product Number: T4295
Tiamulin Fumarate
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Purity: >98.0%(T)
Synonyms:
- Thiamutilin Fumarate
- Tiamulin Hydrogen Fumarate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€50.00
|
Contact Us | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T4295 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__8H__4__7NO__4S·C__4H__4O__4 = 609.82 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 55297-96-6 |
| Reaxys Registry Number | 8533620 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 147.0 to 151.0 °C |
| Specific rotation [a]20/D | +24.0 to +28.0 deg(C=0.5, Dioxane) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 149 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 259-581-6 |
| RTECS# | AG9560000 |
Transport Information:
| HS Number | 2941900000 |
Application
Tiamulin Fumarate: A Pleuromutilin Class Antimicrobial Agent Against Mycoplasma
Tiamulin fumarate, a semisynthetic antimicrobial agent belonging to the pleuromutilin class, is used specifically for treating animals. It is characterized by its potent activity against mycoplasma, as well as Gram-positive and Gram-negative bacteria, in pigs, cattle, sheep, and other poultry. Studies have shown that pleuromutilins bind to domain V of 23S RNA in the ribosomes of pathogenic microorganisms, inhibiting peptidyl transferase and protein synthesis. This results in the death of the microorganisms, exerting antibacterial activity. (The product is for research use only.)
References
- The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome
- Pleuromutilins: potent drugs for resistant bugs-mode of action and resistance (a review)
- Determination of flunixin and tiamulin hydrogen fumarate in meat and toltrazuril and the metabolite toltrazurilsulfon in meat and eggs using LC/MS
- Isolation and structural elucidation of metabolites formed in liver microsomes of pigs
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