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Corey-Fuchs Reaction

The Corey-Fuchs reaction is a two-step reaction sequence used to convert aldehydes into terminal alkynes. The intermediate 1,1-dibromoalkene is produced from aldehydes, triphenylphosphine and carbon tetrabromide during the reaction sequence and can be isolated. This is then converted to the alkyne following the addition of a strong base such as butyllithium.

Reagents: carbon tetrabromide, triphenylphosphine, butyllithium
Reactants: aldehydes
Products: terminal alkynes


Corey-Fuchs reaction

Original literature

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