Published TCIMAIL newest issue No.200
Maximum quantity allowed is 999
Please select the quantity
RhoA Transcriptional Signaling Inhibitor
No.177(April 2018)
CCG-1423 (1) is an inhibitor of Rho signaling.1) The target molecule is myocardin-related transcription factor A (MRTF-A).2) 1 inhibits MRTF-A binding to importin α/β1.
Mouse embryonic stem cells (mESCs) are differentiated to BMP-7-positive cells by treatment in combination with 1 and a PI3K inhibitor, LY294002.3) The combination of these small molecules is also used for differentiation of human induced pluripotent stem cells (iPSCs) to renal progenitors.4)
BMP-7: Bone morphogenetic protein-7
This product is for research purpose only.
References
- 1)CCG-1423: A small-molecule inhibitor of RhoA transcriptional signaling
- 2)RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling
- 3)Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells
- 4)Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.