Published TCIMAIL newest issue No.197
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Xenoantigen and Anti-Xenoantigen Antibodies
Anti-NeuGc Polyclonal Antibodies － Antibodies capable of detecting Neu5Gc epitope
N-Acetylneuraminic Acid (NeuAc) and N-Glycolylneuraminic Acid (NeuGc) are the two major forms of sialic acid found in mammals. Humans are unable to synthesize Neu5Gc due to a mutation in the gene encoding the enzyme responsible for Neu5Gc synthesis. Humans naturally possess antibodies against Neu5Gc glycan structures, and this is responsible for the immunogenicity of therapeutic proteins containing Neu5Gc glycan epitopes. Therefore, a method for the detection of Neu5Gc is required.
Products
*These antibodies are unavailable in the U.S. and China.
Applications
Figure 1. Anti-NeuGc Polyclonal Antibody reacts NeuGc but not NeuAc
Figure 2. Binding of Anti-NeuGc Antibody is inhibited by NeuGcα(2-3)Gal and NeuGcα(2-6)Gal
Figure 3. Detection of NeuGc in miniature pig granulocytes by flow cytometry
Related Products
Anti-αGal Antibodies － Antibodies capable of detecting αGal epitope (Galα1-3Gal)
Anti-αGal antibody exists as a natural antibody in humans. Binding of this antibody to αGal antigens (αGal epitope) expressed on porcine xenograft surfaces are a major factor for determining engraft survival. Recently, it has been observed that therapeutic antibodies and cell processing material for reproductive medicine contain the αGal epitope, which indicates the importance of rapid detection of αGal epitope.
Products
*These antibodies are unavailable in the U.S. and China.
Applications
Figure 4. Anti-αGal antibody can be utilized for detection of the αGal epitope on glycoproteins
Figure 5. Anti-αGal antibody shows the same high specificity compared with an anti-αGal monoclonal antibody
Figure 6. Detection of αGal in miniature pig granulocytes by flow cytometry
![Neu5Gcα(2-3)[GalNAcβ(1-4)]Galβ(1-4)Glc-β-propylamine](/assets/cms-images/xenoantigen_and_anti-xenoantigen_antibodies_N0971.png)
