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Organotrifluoroborates for Cross-coupling leading to Hydroxymethylarenes and Aminomethylarenes

Commonly used as reactants for Suzuki-Miyaura cross-coupling reactions, Organoboronic acids,specifically aryl boronic acids and alkenyl boronic acids, are chemically stable and easy to treat. For such purposes, TCI offers organotrifluoroborate salts that include potassium (methoxymethyl)trifluoroborate [P2153], potassium (acetoxymethyl)trifluoroborate [P2494], potassium (phthalimidomethyl)trifluoroborate [P2514], and potassium (N-Boc-aminomethyl)trifluoroborate [P2155] to allow for more electrically and chemically stable reactions.

P2494, P2153, P2514, P2155

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Applications

Introduction of Hydroxymethyl Groups using P24941)

Introduction of Hydroxymethyl Groups using P2494

Introduction of Methoxymethyl Groups using P21532)

Introduction of Methoxymethyl Groups using P2153

Introduction of Phthalimidomethyl Groups using P25143)

Introduction of Phthalimidomethyl Groups using P2154

Introduction of N-Boc-aminomethyl Groups using P21554)

Introduction of N-Boc-aminomethyl Groups using P2154

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These materials were produced by collaboration with Eisai Co., Ltd.
(Patent No. WO2006098270, WO2008007670)
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