text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Merci de sélectionner la quantité

Dipeptides Degradable by Enzyme in Lysosome

 1, 2, 3, 4, and 5 are dipeptides containing valine (Val)-citrulline (Cit) and p-aminobenzylalcohol (PAB) moieties. It has been reported that Cathepsin B in the lysosome degrades the peptide bond between Cit-PAB.1) Therefore, a drug conjugate bound covalently with carbamate bonds between PAB and the drug can be synthesized by using the dipeptide as a linker. The drug can be then released by hydrolysis after cleavage of the peptide bond between Cit-PAB. Antibody-drug conjugates (ADCs) in which the N-terminus of Val is bound to an antibody have been developed.2)


The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.