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CAS RN: 110078-46-1 | Product Number: P2678

Plerixafor


Purity: >98.0%(GC)
Synonyms:
  • 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene
  • AMD 3100
Documents:
50MG
$101.00
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250MG
$324.00
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Product Number P2678
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__2__8H__5__4N__8 = 502.8  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 110078-46-1
Reaxys Registry Number 4278367
MDL Number

MFCD05662218

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Melting point 131.0 to 135.0 °C
Water max. 13.0 %
Properties (reference)
Melting Point 133 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
Transport Information:
HS Number 2933.99.7500
Application
Plerixafor: A CXCR4 Chemokine Receptor Inhibitor and a Stem Cell Mobilization Agent

Plerixafor (AMD1300) was originally discovered as an anti-HIV agent effective in inhibiting the replication of HIV.1) However, at present, plerixafor has been used as a CXCR4 chemokine receptor inhibitor and a hematopoietic stem cell mobilization agent.2,3) Hematopoietic stem cells express CXCR4, a seven-transmembrane G-protein-coupled chemokine receptor. Plerixafor works as a CXCR4 chemokine receptor antagonist and blocks binding of its cognate ligand, stromal cell-derived factor-1α (SDF-1α). CXCR4 with its ligand SDF-1α has been reported to play an important role in engraftment of hematopoietic stem cells (HSCs) in the bone marrow. Plerixafor results in the rapid and reversible mobilization of hematopoietic stem cells into the peripheral circulation. (The product is for research purpose only.)

References


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