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CAS RN: 68377-91-3 | Product Number: A3145
Arotinolol Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-[2-[[3-(tert-Butylamino)-2-hydroxypropyl]thio]thiazol-4-yl]thiophene-2-carboxamide Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$126.00
|
1 | Contact Us | Contact Us |
|
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| Product Number | A3145 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__1N__3O__2S__3·HCl = 407.99 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 68377-91-3 |
| Related CAS RN | 68377-92-4 |
| Reaxys Registry Number | 10042125 |
| PubChem Substance ID | 354335253 |
| Merck Index (14) | 791 |
| MDL Number | MFCD00941421 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 236 °C(dec.) |
| Solubility (insoluble in) | Diethyl ether, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | XM8301000 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2934.99.4400 |
Application
Arotinolol Hydrochloride: A β-Adrenoceptor Antagonist
Arotinolol hydrochloride (S-596), β-adrenoceptor antagonist, shows high affinities for both β1- and β2-adrenoceptors. Reportedly, It shows a moderate affinity also for α-adrenoceptor, and the mean ratio of α:β = 1:8. In addition, its main metabolite (the 2-thiophenecarboxylic acid, AC-623) also shows affinity for β-adrenoceptors. Arotinolol is widely used in the treatment of high blood pressure. (The product is for research purpose only.)
References
- Studies on Concurrent Alpha-and Beta-adrenoceptor Blocking Action of S-596 (Arotinolol)
- Beta-receptor blocking potencies of the three newly synthesized β-adrenergic antagonists (S-596, K-351, N-696) as assessed with the radioligand binding assay method in rat cardiac muscle membrane treated with neuraminidase
- Effects of S-596, a new beta-adrenoceptor blocking agent on the left ventricular performance of normal subjects during exercise
- High performance liquid chromatographic determination of arotinolol and AC 623, its main metabolite, in biological samples
- Enantiospecific determination of arotinolol in rat plasma by LC-MS/MS: Application to a stereoselective pharmacokinetic study
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