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CAS RN: 127-69-5 | Product Number: U0098
Sulfisoxazole
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Purity: >98.0%(HPLC)
Synonyms:
- 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
- Sulfafurazole
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25G |
$190.00
|
2 | 1 | Contact Us |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | U0098 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__3N__3O__3S = 267.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 127-69-5 |
| Reaxys Registry Number | 263871 |
| PubChem Substance ID | 354335300 |
| Merck Index (14) | 8952 |
| MDL Number | MFCD00003150 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
Properties (reference)
| Melting Point | 195 °C |
| Maximum Absorption Wavelength | 271 nm (MeOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol, Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
| RTECS# | WO9100000 |
Transport Information:
| HS Number | 2935.90.4800 |
Application
Exosome research
Reference
- Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
Application
Sulfisoxazole: A Sulfonamide Antimicrobial
Sulfisoxazole is a sulfonamide antimicrobial which inhibits bacterial synthesis of dihydrofolic acid (DHF) which is needed to make both purines and pyrimidines, are constituents of DNA and RNA. Sulfonamide antimicrobials structurally resemble 4-aminobenzoic acid (PABA)[A0269], a precursor in bacterial DHF synthesis. Therefore, sulfonamide antimicrobials completely inhibit utilization of PABA and synthesis of DHF, and they possess bacteriostatic activity against a broad spectrum of pathogens. Recently, some new antimicrobials bearing sulfisoxazole moiety have been reported.
References
- The Mode of Action of Sulfonamides
- Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture
- Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages
- Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety
- Sulfisoxazole [N1-(3,4-dimethyl-5-isoxazolyl) sulfanilamide] (a review of the analytical profile of sulfisoxazole including synthesis, stability degrdn. and metabolism)
- Multiwalled carbon nanotubes as sorbent for on-line coupling of solid-phase extraction to high-performance liquid chromatography for simultaneous determination of 10 sulfonamides in eggs and pork
PubMed Literature
Documents
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Safety Data Sheet (SDS)
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Specifications
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