Anti-Glycolipid Antibodies

Gangliosides/globosides are cell surface glycosphingolipids composed of glycan and ceramide that play important functional roles in intercellular recognition, cell adhesion, and signal transduction. The carbohydrate moiety of gangliosides/globosides is synthesized in the Golgi apparatus via the sequential action of several glycosyltransferases. Changes in the expression patterns of gangliosides/globosides in development and disease are largely associated with changes in the expression of these glycosyltransferases, which are spatiotemporally regulated at both the transcriptional and post-translational levels. TCI offers antibody products useful for the detection of these glycolipids.