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Chemosynthesis of Sialosides

Sialic acid locates the terminal of sugar chains in glycoproteins, glycolipids, and milk oligosaccharides. Also, sialosides are associated with cell-cell interaction, cell differentiation, and infection of bacteria or viruses. For example, in influenza infections, hemagglutinin on the virus surface links to sialic acid, and the infectious process begins. Also, cancer markers such as CA19-9 (sialyl Lea), SLX (sialyl Lex), STN (sialyl Tn) are carbohydrate antigens that have sialic acid, and are used in cancer diagnosis. However, since the complex sialo-oligosaccharides are obtained in limited quantity from natural sources, for the sake of research promotion, sugar chains of sufficient amount are required. TCI has developed the manufacturing procedure of functional oligosaccharides to supply a variety of sialosides.

Synthesis of Sialosides

 In TCI, kilogram scaled glycosidation of sialic acid is carried out using thioglycoside as the glycosyl donor. Sialic acid and sialyl α(2-3/6) galactose are used as the sugar building blocks for complex sialo-oligosaccharide synthesis. We can prepare the various oligosaccharides having not only N-acetyl neuraminic acid but also N-glycolyl neuraminic acid which does not exist in normal human cells. Chemically synthesized sialo-oligosaccharides having ceramide (ganglioside) and other kind of aglycons such as p-nitrophenyl and aminoalkyl group are prepared. TCI synthesizes a wide range of sugar chains for your daily research. Please feel free to contact us.

Products

A0639
N-Acetylneuraminic Acid Hydrate
A1105
N-Acetylneuraminic Acid
M1706
Methyl 5-Acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-D-galacto-2-nonulopyranosylonate
M2319
Methyl 5-Acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-β-D-galacto-2-nonulopyranosylonate
M2329
Methyl 5-N,4-O-Carbonyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-β-D-galacto-2-nonulopyranosylonate
M2330
Methyl 7,8,9-Tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-β-D-galacto-2-nonulopyranosylonate
M2695
Neu5Ac[1Me,478Ac,9N3]-β-SPh
M2696
Neu5GcAc[1Me,478Ac,9N3]-β-SPh
M1761
Neu5Ac[1Me,4789Ac]α(2-6)Gal[24Bz,3Bn]-β-MP
N0846
Neu5Ac[1Me,4789Ac]α(2-3)Gal[246Bz]-β-MP
M1763
Neu5GcAc[1Me,4789Ac]α(2-6)Gal[24Bz,3Bn]-β-MP
N0816
Neu5GcAc[1Me,4789Ac]α(2-3)Gal[246Bz]-β-MP
N0791
Neu5Acα(2-3)Galβ MP Glycoside
N0792
Neu5Acα(2-6)Galβ MP Glycoside
N0793
Neu5Gcα(2-3)Galβ MP Glycoside
N0794
Neu5Gcα(2-6)Galβ MP Glycoside
N0947
Neu5Acα(2-3)Gal-β-ethylamine
N0948
Neu5Acα(2-6)Gal-β-ethylamine
N0949
Neu5Acα(2-3)Galβ(1-4)GlcNAc-β-ethylamine
N0950
Neu5Acα(2-6)Galβ(1-4)GlcNAc-β-ethylamine
N0853
Neu5Acα(2-3)Galβ(1-3)GlcNAc-β-pNP
N0854
Neu5Acα(2-3)Galβ(1-4)GlcNAc-β-pNP
N0855
Neu5Acα(2-6)Galβ(1-3)GlcNAc-β-pNP
N0856
Neu5Acα(2-6)Galβ(1-4)GlcNAc-β-pNP
N0860
Neu5Acα(2-3)Galβ(1-4)Glc-β-pNP
S0885
3'-Sialyllactose Sodium Salt
S0886
6'-Sialyllactose Sodium Salt
N0890
Neu5Acα(2-6)GalNAc-α-pNP
G0345
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-β-pNP
G0347
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP
G0353
Galβ(1-4)[Neu5Acα(2-6)]GlcNAc-β-pNP
G0377
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP
G0378
GlcNAcβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP
G0440
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-Propylamine
G0422
Ganglioside GM3 (phyto-type)
G0421
Ganglioside GM1 [d18:1, (Carbon-13)C16:0]
G0419
Ganglioside GM3 [d18:1, (Carbon-13)C16:0]
N0971
Neu5Gcα(2-3)[GalNAcβ(1-4)]Galβ(1-4)Glc-β-Propylamine
S0910
Sialyl Neolactotetraosylceramide (=Sialyl nLc4 Cer)
S0849
Sialyl Lewis X-Lactose
S0922
Sialyl Lewis X-Lactose Ethylazide
S0923
Sialyl Lewis X-Lactose Ethylamine
D4217
Disialylnonasaccharide β-Ethylazide
N0913
Disialylnonasaccharide-β-pNP
D4065
Disialyloctasaccharide
S0523
Sialylglycopeptide
Feel free to contact us if you cannot find the product you need.
We would be happy to custom manufacture to your specifications!

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