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Jumonji Domain-containing Histone Demethylase (JHDM) Inhibitor
No.158(July 2013)
Jumonji domain-containing histone demethylase (JHDM) is an enzyme catalyzing the demethylation of
the methylated lysine residue in histone, which regulates the expression of Mdm2 oncogene and p53
anti-oncogene. NCDM-32b (1), developed by Suzuki, Miyata et al., forms NCDM-32 losing a methyl
group of the ester moiety by hydrolytic degradation, and shows an inhibitory activity against JMJD2C, a kind of
JHDM. NCDM-32 inhibits the growth of HCT116 colon cancer cells with a combination of LSD1 inhibitor.
References
- Design, synthesis, enzyme-Inhibitory activity, and effect on human cancer cells of a novel series of Jumonji domain-containing protein 2 histone demethylase inhibitors
Related Compounds
- P0553
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- A2411
- NCL-1•HCl (*This product is discontinued.)
- D4015
- Daminozide
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- Acetyldinaline
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- 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide (= M 344)
- S0892
- Splitomicin
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- Trichostatin A
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- Sodium Butyrate
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- Valproic Acid
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- Valproic Acid Sodium Salt
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