AMP-Activated Protein Kinase (AMPK) Inhibitor

Dorsomorphin (1) is a potent inhibitor of AMP-activated protein kinase (AMPK).¹⁾ AMPK is inhibited by 1 with
Ki = 109 nM. However, 1 does not significantly inhibit structurally related kinases, including spleen tyrosine kinase (SYK), zeta-chain-associated protein kinase (ZAPK), protein kinase A (PKA), protein kinase Cθ (PKCθ), and Janus kinase (JAK).

Additionally, 1 inhibits bone morphogenetic protein (BMP) signaling.²⁾ 1 promotes self-renewal of human embryonic stem cells (hESCs).³⁾ Interestingly, 1 can support stem cell self-renewal over the long term (five or more passes).

This product is for research purpose only.