Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II)

Experimental procedure: In a glovebox, to a vial containing bromobenzene (62 mg, 0.4 mmol), 1 (10.0 mg, 0.02 mmol), pivalic acid (20 mg, 0.2 mmol), K₃PO₄ (168 mg, 0.8 mmol) and DMA (1 mL) is added pentafluorobenzene (98 mg, 0.6 mmol). After stirring at 80 °C for 2-4 h, the reaction is quenched by the addition of NH₄Cl solution. The product is extracted with ethyl acetate (3 x 15 mL) and the combined organic layer is washed with brine and dried with Na₂SO₄. After removal of solvents under vacuum, the crude product is purified by column chromatography (silica gel; hexanes) to give the corresponding product as a colorless oil (86% yield).