Ketorolac Tromethamine: A Non-Selective Cyclooxygenase (COX) Inhibitor with Strong Analgesic Activity
Ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity. Ketorolac is a non-selective cyclooxygenase (COX) inhibitor. Thus, it reduces prostaglandin synthesis. Ketorolac is the racemic mixture of (-)-
S and (+)-
R enantiomers. Most of its analgesic and COX inhibitory activity is retained in the
S-isomer. Besides, some formulations for controlled release of ketorolac tromethamine have been reported. Ketorolac and its metabolites are excreted primarily by the kidneys. For your reference, [
B4934] is used as a synthetic intermediate of ketorolac. (The product is for research purpose only.)