Tobramycin: An Aminoglycoside Antibiotic Active Against Pseudomonas Aeruginosa
Tobramycin is an aminoglycoside antibiotic derived from
Streptomyces tenebrarius, and is similar in structure to gentamicin [
G0383]. Tobramycin interacts with the 30s and 50s subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Tobramycin is more active than gentamicin against
Pseudomonas aeruginosa and active against many gentamicin resistant strains. Recently, inhaled tobramycin is effective in treating chronic
Pseudomonas aeruginosa lung infection in cystic fibrosis. (The product is for research purpose only.)