Xanthohumol

Reference

• Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway
  • X. Mi et al., Oncotarget 2017, 8, 31297.


Anwendung
A Bioactive Polyphenol in Hops and Beer

Xanthohumol is the prenylated chalcone isolated from the female inflorescences of the hop plant (Humulus lupulus L.), an ingredient of beer, have long been used in traditional medicine. Xanthohumol is one of the bioactive substances, and has been reported that it has various pharmacological activities, including antioxidant, anti-inflammatory, anti-proliferative, and osteogenic effects. (The product is for research purpose only)

References

• 1)Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
  • J. F. Stevens, J. E. Page, Phytochemistry 2004, 65, 1317.
• 2)Pharmacognostic and pharmacological profile of Humulus lupulus L.
  • P. Zanoli, M. Zavatti, J. Ethnopharmacol. 2008, 116, 383.
• 3)Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines
  • C. L. Miranda, J. F. Stevens, A. Helmrich, M. C. Henderson, R. J. Rodriguez, Y.-H. Yang, M. L. Deinzer, D. W. Barnes, D. R. Buhler, Food Chem. Toxicol. 1999, 37, 271.
• 4)Cancer chemopreventive activity of xanthohumol, a natural product derived from hop
  • C. Gerhauser, A. Alt, E. Heiss, A. Gamal-Eldeen, K. Klimo, J. Knauft, I. Neumann, H. Scherf, N. Frank, H. Bartsch, H. Becker, Mol. Cancer Ther. 2002, 1, 959.
• 5)Bone resorption inhibitors from hop extract
  • H. Tobe, Y. Muraki, K. Kitamura, O. Komiyama, Y. Sato, T. Sugioka, H. B. Maruyama, E. Matsuda, M. Nagai, Biosci. Biotechnol. Biochem. 1997, 61, 158.
• 6)Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro
  • C. L. Miranda, J. F. Stevens, V. Ivanov, M. McCall, B. Frei, M. L. Deinzer, D. R. Buhler, J. Agric. Food Chem. 2000, 48, 3876.
• 7)Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus
  • N. Tabata, M. Ito, H. Tomoda, S. Omura, Phytochemistry 1997, 46, 683.


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