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Water-soluble Biocompatible Polymers: Poly(2-oxazoline)s
Poly(2-oxazoline)s are biocompatible and non-immunogenic pseudo-polypeptide-structured polymers. ULTROXA® Poly(2-methyl-2-oxazoline) [P2506], a highly-defined polymer with narrow molar mass distribution developed by Ghent University, is more hydrophilic than poly(ethylene glycol) (PEG). ULTROXA® Poly(2-propyl-2-oxazoline) [P2508] transitions to a hydrophobic state in water when heated. Poly(2-oxazoline)s are applicable to surface coating, drug delivery systems, and thermoresponsive material.
Advantage
• Biocompatible and non-immunogenic pseudo-polypeptide structure
• P2506 is more hydrophilic than poly(ethylene glycol) (PEG).
• P2508 transitions to a hydrophobic state in water when heated. (Low Critical Solution Temperature (LCST) : ca. 25°C)
• P2506 is more hydrophilic than poly(ethylene glycol) (PEG).
• P2508 transitions to a hydrophobic state in water when heated. (Low Critical Solution Temperature (LCST) : ca. 25°C)
Applications
Surface Coating with Protein-repellent or Nonfouling Properties
- R. Konradi, B. Pidhatika, A. Mühlebach, M. Textor, Langmuir 2008, 24, 613.
- R. Konradi, C. Acikgoz, M. Textor, Macromol. Rapid Commun. 2012, 33, 1663.
Drug Delivery Systems
- T. X. Viegas, M. D. Bentley, J. M. Harris, Z. Fang, K. Yoon, B. Dizman, R. Weimer, A. Mero, G. Pasut, F. M. Veronese, Bioconjugate Chem. 2011, 22, 976.
- H. Bludau, A. E. Czapar, A. S. Pitek, S. Shukla, R. Jordan, N. F. Steinmetz, Eur. Polym. J. 2017, 88, 679.
Thermoresponsive Material
- R. Hoogenboom, H. M. L. Thijs, M. J. H. C. Jochems, B. M. van Lankvelt, M. W. M. Fijten, U. S. Schubert, Chem. Commun. 2008, 0, 5758.
- M. A. Boerman, H. L. V. der Laan, J. C. M. E. Bender, R. Hoogenboom, J. A. Jansen, S. C. Leeuwenburgh, J. C. M. V. Hest, J. Polym. Sci. A. 2016, 54, 1573.
- M. Mees, E. Haladjova, D. Momekova, G. Momekov, P. S. Shestakova, C. B. Tsvetanov, R. Hoogenboom,
S. Rangelov, Biomacromolecules 2016, 17, 3580.