Maintenance Notice (12:30 AM - 5:30 AM August 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Bitte wählen Sie die Menge aus.
Useful Chiral Dirhodium(II) Complex Catalyst
No.144(March 2011)
- T2658
- Tetrakis[N-tetrachlorophthaloyl-(R)-tert-leucinato]dirhodium Bis(ethyl Acetate) Adduct (1a)
- T2659
- Tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinato]dirhodium Bis(ethyl Acetate) Adduct (1b)
- T2660
- Tetrakis[N-tetrafluorophthaloyl-(R)-tert-leucinato]dirhodium Bis(ethyl Acetate) Adduct (2a) (*This product is discontinued.)
- T2661
- Tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinato]dirhodium Bis(ethyl Acetate) Adduct (2b)
Hashimoto et al. have developed chiral dirhodium(II) complexes,
Rh2(R-PTTL)4, Rh2(S-PTTL)4,
Rh2(R-TCPTTL)4, Rh2(S-TCPTTL)4,
Rh2(R-TFPTTL)4 and Rh2(S-TFPTTL)4, and reported their
usefulness. According to their results, intramolecular C-H insertion reactions, 1,3-dipolar cycloaddition of
carbonyl ylides and amination of silyl enol ethers are catalyzed by these dirhodium(II) complexes to proceed
highly enantioselectively and give corresponding products in high yields.
Typical Procedure: 1)
A solution of diazo compound 3 (60.5 mg, 0.20 mmol) and styrene (62.5 mg, 0.60 mmol) in CF3C6H5 (1.0 mL) is added via syringe pump over 1 h to a stirred solution of 1b (3.95 mg, 0.002 mmol, 1 mol%) in CF3C6H5 (1.0 mL). After complete addition, the reaction mixture is concentrated in vacuo, and the residue is purified by column chromatography (silica gel, hexane:EtOAc = 6:1) to provide 4 (64.5 mg, Y. 85%) as a white solid.
A solution of diazo compound 3 (60.5 mg, 0.20 mmol) and styrene (62.5 mg, 0.60 mmol) in CF3C6H5 (1.0 mL) is added via syringe pump over 1 h to a stirred solution of 1b (3.95 mg, 0.002 mmol, 1 mol%) in CF3C6H5 (1.0 mL). After complete addition, the reaction mixture is concentrated in vacuo, and the residue is purified by column chromatography (silica gel, hexane:EtOAc = 6:1) to provide 4 (64.5 mg, Y. 85%) as a white solid.
References
- 1) Enantioselective 1,3-dipolar cycloaddition of carbonyl ylide
- 2) Enantioselective amination of silyl enol ether
Related Compounds
The prices are subject to change without notice. Please confirm the newest price by our online
catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.