Maintenance Notice (12:30 AM - 5:30 AM August 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Bitte wählen Sie die Menge aus.
DRB: A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
No.164(January 2015)
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB, 1) is a selective inhibitor of transcription elongation by RNA polymerase II, further inhibiting mRNA synthesis in eukaryotic cells.1) The inhibition can trigger p53-dependent apotosis of tumor cells.2) DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat)3).
References
- 1)Selective inhibitation of transcription elongation
- 2)Inhibition of RNA polymerase II as a trigger for the p53 response
- 3)Inhabitation of HIV transcription
Related Compounds
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.