O-Desmethylvenlafaxine: An Active Metabolite of Venlafaxine Belonging to SNRIs
O-Desmethylvenlafaxine (desvenlafaxine, or ODV) is an active metabolite of venlafaxine [
V0110] which belongs to a serotonin [
S0370] /norepinephrine [
A0906] reuptake inhibitors (SNRIs). It is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine [
A0305] reuptake. It has no significant affinity for muscarinic cholinergic, H
1-histaminergic, or α
1-adrenergic receptors
in vitro. (The product is for research purpose only.)