Published TCIMAIL newest issue No.200
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γ-Secretase Inhibitor
DAPT (1) is a γ-secretase inhibitor and a dose-dependent reducer of brain amyloid β-peptide (Aβ) levels.1) It was also demonstrated that 1 disrupts Notch signaling indirectly.2)
Notch pathway functions during diverse developmental and physiological processes and is highly conserved throughout the animal kingdom.3) It was reported that inhibition of the Notch response by 1 resulted in enhanced neuronal differentiation in embryonic stem cell-derived embryoid bodies and the enhancement is independent on sonic hedgehog signaling.4)
References
- 1)Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
- 2)The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins
- 3)Notch signaling: A simple pathway becomes complex
- 4)The Notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling
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