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三氟甲基化反应 [合成试剂]

 The size of a fluorine atom is similar to a hydrogen atom but the electric property of it is more electronegative. So, by replacing a hydrogen atom of substances with a fluorine atom, their biological properties can be dramatically changed without a conformational change. Recently, the synthetic and biological studies of fluorinated molecules have attracted a lot of interest in the fields of pharmaceuticals and agrochemicals research. Especially, the synthetic study of the trifluoromethyl group-containing compounds is now actively proceeding.
 As a method for direct trifluoromethylation, nucleophilic and electrophilic/radical fluorinating reactions are commonly used. Ruppert-Prakash reagent ((Trifluoromethyl)trimethylsilane) (T0570) is the most popular nucleophilic trifluoromethylating reagent and which readily reacts with a fluoride ion to release the trifluoromethylanion species. This active species shows nucleophilicity and reacts with carbonyl compounds to proceed with the trifluoromethylation.1) Also, the nucleophilic trifluoromethylation of aromatic halides can be performed with the use of copper catalysts.2)
 The study of electrophilic trifluoromethylations has lagged compared to that of nucleophilic trifluoromethylations. However, recently some reagents usable for electrophilic trifluoromethylation have been reported. Shibata et al. have developed an electrophilic α-trifluoromethylation of β-ketoesters using the fluorinated Johnson reagent (O0367).3) The hypervalent iodine(III)–CF3 reagents (T2624 and T3014) developed by Togni et al. are widely used for trifluoromethylations of thiols, alcohols, phosphines, and heteroarenes.4) Also, Baran et al. have reported the radical trifluoromethylation of heteroarenes using the Langlois reagent (T2033) or zinc(II) bis(trifluoromethanesulfinate) (Zn(SO2CF3)2) (Z0028) with tert-butyl hydroperoxide.5)
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产品编码 T2624
CAS RN 887144-97-0
纯度/分析方法 >97.0%(HPLC)

产品编码 T1336
CAS RN 2923-18-4
纯度/分析方法 >98.0%(T)

产品编码 P2195
CAS RN 426-58-4
纯度/分析方法 >98.0%(GC)

产品编码 P2460
CAS RN 703-18-4
纯度/分析方法 >98.0%(GC)

产品编码 F0311
CAS RN 680-15-9
纯度/分析方法 >97.0%(GC)

产品编码 P2172
CAS RN 1334890-93-5
纯度/分析方法 >95.0%(T)

产品编码 B1616
CAS RN 14353-88-9
纯度/分析方法 >97.0%(T)

产品编码 T3592
CAS RN 15458-53-4
纯度/分析方法 >95.0%(GC)

产品编码 Z0028
CAS RN 39971-65-8
纯度/分析方法 >98.0%(T)

产品编码 T2764
CAS RN 120120-26-5
纯度/分析方法 >98.0%(GC)

产品编码 P2036
CAS RN 626232-27-7
纯度/分析方法 >95.0%(T)

产品编码:   T2624 | 纯度/分析方法   >97.0%(HPLC)

产品编码:   T1336 | 纯度/分析方法   >98.0%(T)

产品编码:   P2195 | 纯度/分析方法   >98.0%(GC)

产品编码:   P2460 | 纯度/分析方法   >98.0%(GC)

产品编码:   F0311 | 纯度/分析方法   >97.0%(GC)

产品编码:   B1616 | 纯度/分析方法   >97.0%(T)

产品编码:   T3592 | 纯度/分析方法   >95.0%(GC)

产品编码:   Z0028 | 纯度/分析方法   >98.0%(T)

产品编码:   T2764 | 纯度/分析方法   >98.0%(GC)

产品编码:   P2036 | 纯度/分析方法   >95.0%(T)

  • 1(current)
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