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花菁 [荧光标记试剂]

Heptamethine cyanine dyes in the near-infrared window

Cyanine dyes, including Cyanine3, Cyanine5, Cyanine5.5, Cyanine 7 and Indocyanine Green (ICG) [I0535] are important compounds in biological applications. Among them, ICG, which is a heptamethine cyanine dye, has an absorption wavelength and an emission wavelength in the near-infrared window (about 800 nm), and is used for ophthalmic angiography and examining cardiac output, hepatic function, gaster/liver bloodstream. But ICG is nonspecific and cannot stain a certain tissue. Alternatively, researchers have been trying to utilize conjugates of heptamethine cyanine dye, which has functional group, with proteins including antibodies for diagnosis of a specific disease, drug release in a specific tissue, or fluorescence-guided surgery.1-6) In particular, NIR fluorophore-mAb conjugates, which are complexes with monoclonal antibodies (mAbs), are useful as contrast agents for tumor targeting. As a near-infrared dye that can be conjugated with such antibodies, we introduce a cyanine dye that was added a carboxyl group into the polymethine structure of ICG.7,8) ICG Carboxylic Acid [O0574] can be expected to be used as a material with characteristics that are close to but different from ICG, such as solubility and specific reactivity with biomolecules. For example, a probe for cellular hypoxia imaging that can "turn on" fluorescence with nitroreductase has been reported.9)

We offer ICG Carboxylic Acid at a lower price than ICG. We have 1 g and 5 g packages, and will be happy to discuss bulk synthesis requests.

Indocianine Green (= ICG)

ICG Carboxylic Acid

IR 754 Carboxylic Acid

IR 775 Chloride

IR 783

In addition to ICG Carboxylic Acid, we also offer IR 754 Carboxylic Acid [C3693], IR 775 Chloride [I1026] and IR 783 [I1031]. IR 783 can be used for conjugation with proteins such as antibodies because the functional group that can be conjugated with alcohol, amine, thiol and phenylboronic acid can be introduced into the chlorine moiety of the polymethine chain.2,10)


Fluorescence/Absorption Spectra

Fluorescence Spectra of ICG

Fluorescence Spectra of ICG Carboxylic Acid

Fluorescence Spectra of IR 754 Carboxylic Acid

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For labeling Amino Groups 11,12)

Labeling for Amino Groups

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5 项结果 显示
查看:  名单
产品编码 C3567
CAS RN 146368-13-0
纯度/分析方法 >98.0%(HPLC)

产品编码 I1031
CAS RN 115970-66-6
纯度/分析方法 >98.0%(HPLC)

产品编码 I1026
CAS RN 199444-11-6
纯度/分析方法 >90.0%(N)

产品编码 C3693
CAS RN 2311980-68-2
纯度/分析方法 >80.0%(HPLC)

产品编码 O0574
纯度/分析方法 >80.0%(T)(HPLC)

产品编码:   C3567 | 纯度/分析方法   >98.0%(HPLC)

产品编码:   I1031 | 纯度/分析方法   >98.0%(HPLC)

产品编码:   I1026 | 纯度/分析方法   >90.0%(N)

产品编码:   C3693 | 纯度/分析方法   >80.0%(HPLC)

产品编码:   O0574 | 纯度/分析方法   >80.0%(T)(HPLC)