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CAS RN: 94749-08-3 | 产品编码: A3190

Salmeterol Xinafoate


纯度/分析方法: >98.0%(T)(HPLC)
别名:
  • 昔美酸沙美特罗
  • 4-[1-羟基-2-[[6-(4-苯基丁氧基)己基]氨基]乙基]-2-(羟甲基)苯酚1-羟基-2-萘甲酸盐
  • 4-[1-Hydroxy-2-[[6-(4-phenylbutoxy)hexyl]amino]ethyl]-2-(hydroxymethyl)phenol 1-Hydroxy-2-naphthoate
文档:
250MG
¥1,990.00
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产品编码 A3190
纯度/分析方法 >98.0%(T)(HPLC)
分子式/分子量 C__2__5H__3__7NO__4·C__1__1H__8O__3 = 603.76 
外观与形状(20°C) 固体
CAS RN 94749-08-3
相关CAS RN 89365-50-4
Reaxys-RN 9833043
PubChem物质ID 354335558
Merck Index (14) 8337
MDL编号

MFCD00897708

技术规格
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 %(total of Ion-Pair)
Purity(Neutralization titration) min. 98.0 %
物性(参考值)
熔点 138 °C(dec.)
水溶性 不溶
溶解性(可溶于) 甲醇
溶解性(微溶于) 乙醇
溶解性(不溶于) 二乙醚
GHS
相关法规
RTECS# QJ1970500
新化学物质备案回执号 B1A232214864
运输信息
监管条件代码(*)
应用
Salmeterol Xinafoate: A Selective and Long-Acting β2-Adrenergic Receptor Agonist

A3190

Salmeterol xinafoate is a selective and long-acting β2-adrenergic receptor agonist. In vitro and in vivo studies demonstrate that salmeterol is selective for β2- adrenergic receptors compared with isoproterenol [I0260], which has approximately equal agonist activity on β1 and β2- adrenergic receptors. The pharmacologic effects of β2-adrenergic receptor agonist agents, including salmeterol, attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) [A0157 (2Na salt)] to cyclic-3’,5’-adenosine monophosphate (c-AMP) [A2381, A2112 (Na salt)]. Increased c-AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of inflammatory mediators from cells, especially from mast cells.
The mechanism of action for long-acting is explained as follows. Salmeterol consists of a saligenin ethanolamine “head” with a large lipophilic “tail” or side chain. Because of the side chain is anchored at the exo-site, the active “head” portion continually attaches to and detaches from the receptor site. (The product is for research purpose only.)

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