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CAS RN: 112022-81-8 | 产品编码: D2131
(S)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine
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纯度/分析方法: >98.0%(T)
别名：
- (S)-5,5-二苯基-2-甲基-3,4-丙醇-1,3,2-噁唑硼烷
- (S)-3,3-二苯基-1-甲基四氢-1H,3H-吡咯并[1,2-c][1,3,2]噁唑硼烷
- (S)-Me-CBS催化剂
- (S)-(-)-甲基-CBS-噁唑硼烷
- (S)-3,3-Diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
- (S)-Me-CBS Catalyst
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* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
* 无具体发货日期的情况，如：显示“8个工作日后发货”，将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 95.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -66.0 to -73.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 比旋光度 [α]D | -68° (C=1,MeOH) |
| 溶解性（微溶于） | 甲醇 |
GHS
相关法规
运输信息
| 监管条件代码(*) |
应用
Corey-Bakshi-Shibata Reduction (CBS Reduction)
Typical Procedure:
A freshly prepared solution of 0.5 M dimethyl sulfide borane in toluene (48 µL, 0.024 mmol) is added to a solution of 1 (4.5 mg, 0.012 mmol) and 0.05 M (S)-Me-CBS catalyst in toluene (470 µL, 0.024 mmol) at -78 °C under N2 atmosphere. After the mixture is stirred for 15 h at -30 ℃, methanol (100 µL) is added, followed by water (0.5 mL) and Et2O (2 mL), and the mixture is warmed to 23 ℃. Water (10 mL) and Et2O (10 mL) are added, and the aqueous portion is extracted with Et2O (2 x 20 mL). The combined organic fractions are dried (MgSO4) and concentrated in vacuo. Flash chromatography (SiO2, Et2O : hexane = 8 : 92) affords 2 (4.1 mg, 91% yield) as a clear oil.
A freshly prepared solution of 0.5 M dimethyl sulfide borane in toluene (48 µL, 0.024 mmol) is added to a solution of 1 (4.5 mg, 0.012 mmol) and 0.05 M (S)-Me-CBS catalyst in toluene (470 µL, 0.024 mmol) at -78 °C under N2 atmosphere. After the mixture is stirred for 15 h at -30 ℃, methanol (100 µL) is added, followed by water (0.5 mL) and Et2O (2 mL), and the mixture is warmed to 23 ℃. Water (10 mL) and Et2O (10 mL) are added, and the aqueous portion is extracted with Et2O (2 x 20 mL). The combined organic fractions are dried (MgSO4) and concentrated in vacuo. Flash chromatography (SiO2, Et2O : hexane = 8 : 92) affords 2 (4.1 mg, 91% yield) as a clear oil.
References
- Total Synthesis of Dysidiolide
PubMed Literature