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CAS RN: 2207-75-2 | 产品编码: O0164

Potassium Oxonate


纯度/分析方法: >98.0%(T)(HPLC)
别名:
  • 氧嗪酸钾
  • 尿囊毒酸钾
  • 草酰钾
  • 4,6-二羟基-1,3,5-噻嗪-2-羧酸钾盐
  • Allantoxanic Acid Potassium Salt
  • Oxonic Acid Potassium Salt
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文档:
5G
¥275.00
14   4   ≥20 
25G
¥1,005.00
≥20  2   ≥20 
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产品编码 O0164
纯度/分析方法 >98.0%(T)(HPLC)
分子式/分子量 C__4H__2KN__3O__4 = 195.18  
外观与形状(20°C) 固体
CAS RN 2207-75-2
相关CAS RN 937-13-3
Reaxys-RN 4049961
PubChem物质ID 87574167
MDL编号

MFCD00010565

技术规格
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
物性(参考值)
熔点 300 °C
GHS
相关法规
RTECS# RR4580000
新化学物质备案回执号 B1A232215171
运输信息
监管条件代码(*)
应用
Potassium Oxonate: An Inhibitor of Orotate Phosphoribosyltransferase (OPRT)

Potassium oxonate is an inhibitor of orotate phosphoribosyltransferase (OPRT) that is an enzyme involved in the biosynthesis of pyrimidine nucleotides and catalyzes the phosphorylation of 5-FU [F0151] to an active metabolite 5-fluorouridine-5'-monophosphate (FUMP). The gastrointestinal toxicity (GIT) of the oral administration of 5-FU is also caused by the phosphorylation by OPRT in the gut wall. Potassium oxonate selectively and competitively inhibits OPRT. As a result, 5-FU associated gastrointestinal toxic effects are reduced. Potassium oxonate is often used as combined agents to enhance the antitumor activity of fluoropyrimidines, such as S-1 (tegafur [F0635] a prodrug of 5-FU, gimeracil [C2243] and potassium oxonate at a molar ratio of 1:0.4:1). (The product is for research purpose only.)

References


应用
Reagent for hyperuricemia (gout) model

References


参考文献


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