CAS RN: 7240-38-2 | 产品编码: O0353
Oxacillin Sodium Salt Monohydrate
This product has not been tested for potency and is guaranteed for chemical purity.
|Appearance||White to Almost white powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Purity(Volumetric Analysis)||min. 95.0 %|
|Specific rotation [a]20/D||+200.0 to +210.0 deg(C=1, H2O)(calcd.on anh.substance)|
|Water||3.5 to 5.0 %|
|比旋光度 [α]D||205° (C=1,H2O)|
Oxacillin Sodium: A β-Lactamase-Resistant Penicillin
Oxacillin sodium, an isoxazolyl penicillin, is chemically synthesized from 6-APA [A0800] and [M2996]. Oxacillin has activity against Gram-positive bacteria, but less activity against Gram-negative bacteria, the same as penicillin G [P1770] [P1772]. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Meanwhile, oxacillin, cloxacillin [C2244] and methicillin are resistant to the enzymes (β-lactamases) which produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins, due to theirs large side-chain, which does not allow the β-lactamases to bind. However, with the widespread use of oxacillin, antibiotic-resistant strains called oxacillin-resistant Staphylococcus aureus (ORSA) have become increasingly prevalent worldwide.
- A survey of the kinetic parameters of class C β-lactamases. Penicillins
- Contributions of the AmpC β-lactamase and the acrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to β-lactams
- Methicillin (oxacillin)-resistant Staphylococcus aureus strains isolated from major food animals and their potential transmission to humans
- Detection of methicillin/oxacillin resistance in staphylococci