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CAS RN: 599-79-1 | 产品编码: S0580

Sulfasalazine


纯度/分析方法: >95.0%(T)(HPLC)
别名:
  • 柳氮磺胺吡啶
  • 5-[4-(2-吡啶胺磺酰基)苯偶氮基]水杨酸
  • 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid
文档:
25G
¥880.00
2   2   ≥20 
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产品编码 S0580
纯度/分析方法 >95.0%(T)(HPLC)
分子式/分子量 C__1__8H__1__4N__4O__5S = 398.39  
外观与形状(20°C) 固体
应避免的情况
CAS RN 599-79-1
Reaxys-RN 356241
PubChem物质ID 87560165
Merck Index (14) 8942
MDL编号

MFCD00057363

技术规格
Appearance Light yellow to Amber to Dark green powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Neutralization titration) min. 95.0 %
物性(参考值)
熔点 246 °C(dec.)
水溶性 不溶
溶解性(微溶于)
溶解性(不溶于) 氯仿,苯,乙醚
GHS
象形图 Pictogram
信号词 警告
危险性说明 H351 : 怀疑致癌。
防范说明 P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑:求医/就诊。
P405 : 存放处须加锁。
相关法规
RTECS# VO6250000
物流信息
监管条件代码(*)
应用
Sulfasalazine: A Prodrug of 5-Aminosalicylic Acid (5-ASA), a NF-κB Inhibitor and an xCT Inhibitor

Sulfasalazine (salazosulfapyridin) is formed by combining sulfapyridine and salicylate with an azo bond. Sulfasalazine is split by intestinal bacteria to two main matabolites, sulfapyridine [S0071] and 5-aminosalicylic acid (5-ASA) [A0317], and the 5-ASA shows anti-inflammatory effects. Sulfasalazine is used as a gastrointestinal anti-inflammatory agent and is known as a potent inhibitor of NF-κB. Sulfasalazine is commonly used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease (CD) and rheumatoid arthritis (RA).
Recently, the antitumor effects of sulfasalazine have attracted attention. CD44v is an adhesion molecule expressed in cancer stem-like cells. CD44v interacts with xCT, a glutamate-cysteine transporter, keeping high levels of the intracellular reduced glutathione (GSH) which an important antioxidant and stabilizer in cell. Sulfasalazine works as an xCT inhibitor, and suppresses CD44v-dependent tumor growth and increases sensitivity to cytotoxic drugs. (The product is for research purpose only.)

References


参考文献


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