Linker Molecule for CNTs/Graphene FET Biosensors: PBASE

1-Pyrenebutanoic Acid Succinimidyl Ester (PBASE) is one of the frequently used linkers for the surface modification of FET biosensors based on carbon nanotubes (CNTs) and graphene.
The pyrene moiety of PBASE and the CNTs/graphene surface form non-covalent bonds through π-π stacking interactions. Therefore, when subsequently reacted with a biomolecule containing amino groups, PBASE immobilizes any biomolecules while preserving the structure and function of CNTs/graphene surfaces.

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References

1. 1) Noncovalent Sidewall Functionalization of Single-Walled Carbon Nanotubes for Protein Immobilization
   • R. J. Chen, Y. Zhang, D. Wang, H. Dai, J. Am. Chem. Soc. 2001, 123, 3838.
2. 2) Sensors Based on the Carbon Nanotube Field-Effect Transistors for Chemical and Biological Analyses
   • Y. Deng, L. Liu, J. Li, L. Gao, Biosensors 2022, 12, 776.
3. 3) A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers
   • J. Sethi, G. Pan, et al., Microchim. Acta 2020, 187, 288.

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