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Direct Cyanomethylation of Nitroarenes
No.126(August 2007)

(Phenylthio)acetonitrile (1) can react with nitroarenes and introduce a cyanomethyl group at the ortho- or para- position to the nitro group.1 The resulting o-nitroarylacetonitrile 2, for example, is a useful starting material for the synthesis of nitrogen-containing fused ring compounds.2
References
- 1)Vicarious substitution of hydrogen in aromatic nitro compounds
- 2)The synthesis of N-containing fused ring compounds
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