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Published TCIMAIL newest issue No.201
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CAS RN: 33564-30-6 | Product Number: C3602
Cefoxitin Sodium
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Sodium (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
58,00 €
|
2 | ≥40 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C3602 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6N__3NaO__7S__2 = 449.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 33564-30-6 |
| Reaxys Registry Number | 4104290 |
| PubChem Substance ID | 468591188 |
| Merck Index (14) | 1936 |
| MDL Number | MFCD00079042 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +202 to +210 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C |
| Specific Rotation | 209° (C=1,MeOH) |
| Maximum Absorption Wavelength | 260 nm (H__2O) |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Aliphatic hydrocarbons |
GHS
Related Laws:
| EC Number | 251-574-6 |
| RTECS# | XI0330500 |
Transport Information:
| HS Number | 2941900000 |
Application
Cefoxitin Sodium: A Second Generation Cephem Antibiotic against beta-Lactamase
Cefoxitin sodium and its free acid [C3598] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1,2) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases.1,3)
References
- 1) Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use
- 2) Bioavailability and pharmacokinetics of cefoxitin sodium (a review)
- 3) AmpC β-Lactamases (a review)
- 4) Cefoxitin, Sodium (A Review on the Properties, Synthesis, Stability, Metabolism, and Methods of Determination of Cefoxitin Sodium)
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