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Published TCIMAIL newest issue No.199
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CAS RN: 1508-75-4 | Product Number: T1470
Tropicamide
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Purity: >99.0%(T)(HPLC)
Synonyms:
- N-Ethyl-N-(4-pyridylmethyl)tropamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10G |
€139.00
|
1 | 16 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T1470 |
Purity / Analysis Method 
|
>99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__0N__2O__2 = 284.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1508-75-4 |
| Reaxys Registry Number | 285563 |
| PubChem Substance ID | 87577232 |
| Merck Index (14) | 9780 |
| MDL Number | MFCD00058580 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 97.0 to 100.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 98 °C |
| Maximum Absorption Wavelength | 254 nm (HCl aq.) |
| Solubility (soluble in) | Chloroform, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 216-140-2 |
| RTECS# | CY1487860 |
Transport Information:
| HS Number | 2933399999 |
Application
Tropicamide: A Muscarinic M4 Receptor Antagonist
Tropicamide is a muscarinic M4 receptor antagonist. Tropicamide produces short acting cycloplegia and mydriasis when applied as eye drops. Tropicamide has an action similar to atropine [A0754], but its cycloplegic and mydriatic effects have a more rapid onset and a shorter duration of effect. Tropicamide is slightly soluble in water and in diethyl ether, freely soluble in ethanol and in chloroform. (The product is for research purpose only.)
References
- The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors
- The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide
- Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery
- Tropicamide (a review on the physical properties, synthesis, stability, metabolism and analysis)
- High-performance liquid chromatographic determination of phenylephrine and tropicamide in human aqueous humor
PubMed Literature
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