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CAS RN: 60-54-8 | Product Number: T3971
Tetracycline
×
Purity: >95.0%(T)(HPLC)
Synonyms:
- (4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€57.00
|
7 | ≥100 |
|
|
| 25G |
€91.00
|
9 | 5 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T3971 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__8 = 444.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 60-54-8 |
| Reaxys Registry Number | 2230417 |
| PubChem Substance ID | 468593045 |
| Merck Index (14) | 9196 |
| MDL Number | MFCD00151232 |
Specifications
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 %(calcd. on anh. substance) |
| Water | max. 5.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 164 °C(dec.) |
| Maximum Absorption Wavelength | 357 nm (H__2O) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 231 mg/l 25 °C |
| Solubility (slightly sol. in) | Alcohol |
| Solubility (insoluble in) | Chloroform, Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-481-9 |
| RTECS# | QI8750000 |
Transport Information:
| HS Number | 2941300000 |
Application
Biofilm research
Susceptibility of Actinobacillus actinomycetemcomitans, strain 310a, biofilm to tetracycline has been reported. Adding 0.1 or 1 mg/L of the antibiotic significantly inhibited the biofilm formation in the early phase, but not in the mature phase.1) Although adding 10 mg/L of the antibiotic reduced biofilm development in the early phase, it enhanced biofilm development in the mature phase.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
- 1) Inhibition of Trypsin-Like Cysteine Proteinases (Gingipains) from Porphyromonas gingivalis by Tetracycline and Its Analogues
- Single-stranded DNA aptamers specific for antibiotics tetracyclines
- Tetracyclines. Antibiotic action, uptake, and resistance mechanisms (a review)
- Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
- The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
- Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution (a review)
- Update on acquired tetracycline resistance genes
- In vivo gene regulation using tetracycline-regulatable systems
Application
Gingipain inhibitor
Tetracycline has been reported to inhibit gingipains, arginine-specific gingipains (HRgpA and RgpB), and lysine-specific gingipain (Kgp) from Porphyromonas gingivalis.1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
Application
DNA aptamer research
Reference
Application
Tetracycline: a Broad Spectrum Polyketide Antibiotic and a Selective Reagent Genetically Engineered Cells
Tetracycline is a polyketide antibiotic isolated from Streptomyces genus. Tetracycline has broad activity against Gram-negative bacteria and Gram-positive bacteria, with a few exceptions, such as Pseudomonas aeruginosa and Proteus species. Tetracycline inhibits protein synthesis in susceptible organisms by binding to the A-site on the 50S subunit of a bacterial ribosome. However, tetracycline-resistant bacterial strains appeared soon after its introduction. Tetracycline is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for tetracycline resistance, which is one of the most frequently used selection markers for obtaining transgenic cells. Recently, tetracycline is used for tetracycline-controlled transcriptional activation systems in cells. (The product is for research purpose only.)
References
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