Atipamezole hydrochloride is a potent and selective α
2-adrenoceptor antagonist with an imidazole structure. In animals, it promotes the release of the neurotransmitter noradrenaline in the central as well as in the peripheral nervous systems. The α
2/α
1 selectivity ratio are considerably higher than those of yohimbine hydrochloride [
Y0002]. Unlike many other α
2-adrenoceptor antagonists, atipamezole has negligible affinity for 5-HT
1A receptors. Atipamezole hydrochloride is used for the reversal of an α
2-agonist (e.g. xylazine hydrochloride [
X0059]) induced sedation in animals. (The product is for research purpose only.)