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Published TCIMAIL newest issue No.198
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CAS RN: 31677-93-7 | Product Number: B3649
Bupropion Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(tert-Butylamino)-1-(3-chlorophenyl)-1-propanone Hydrochloride
- Amfebutamone Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€41.00
|
2 | 7 |
|
| 5G |
€143.00
|
3 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B3649 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__8ClNO·HCl = 276.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 31677-93-7 |
| Related CAS RN | 34911-55-2 |
| Reaxys Registry Number | 6161273 |
| PubChem Substance ID | 125307968 |
| SDBS (AIST Spectral DB) | 52948 |
| Merck Index (14) | 1499 |
| MDL Number | MFCD00055209 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 222 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 250-759-9 |
| RTECS# | UG8858000 |
Transport Information:
| HS Number | 2922390090 |
Application
Bupropion Hydrochloride: a Dopamine-Norepinephrine Reuptake Inhibitor and a Nicotinic Antagonist
Bupropion hydrochloride is presumed to be a norepinephrine-dopamine reuptake inhibitor (NDRI) and a nicotinic antagonist. Bupropion is metabolized in liver by cytochrome P 450 2B6 (CYP2B6) to hydroxybupropions which are believed to contribute to antidepressant and perhaps smoking cessation activities.
References
- Bupropion is a nicotinic antagonist
- CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants
- Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity
- Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance
- Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice
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