Published TCIMAIL newest issue No.201
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 2140-77-4 | Product Number: M3745
N2-Methylguanosine
×
Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-(methylamino)-1,9-dihydro-6H-purin-6-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
150,00 €
|
Contact Us | 24 |
|
|
| 50MG |
350,00 €
|
Contact Us | 29 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M3745 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__1H__1__5N__5O__5 = 297.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 2140-77-4 |
| Reaxys Registry Number | 46491 |
| MDL Number | MFCD00057039 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 233 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
N2-Methylguanosine: A Modified Nucleoside Found in the tRNA of Nearly All Archaea and Eukaryotes
N2-Methylguanosine (m2G) is a modified nucleoside found in the tRNA of nearly all archaea and eukaryotes but not in bacteria. It plays crucial roles in the control and stabilization of tRNA.1-3) In addition, it has been reported that some modified nucleosides, including N2-methylguanosine, are excreted in abnormal amounts in the urine of patients with malignancies. Thus, the modified nucleosides may be useful tumor markers.4,5)
References
- 1) Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA
- 2) Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14
- 3) iRNA-m7G: Identifying N7-methylguanosine Sites by Fusing Multiple Features
- 4) Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control
- 5) Liquid chromatography tandem mass spectrometry study of urinary nucleosides as potential cancer markers
Product Documents (Note: Some products will not have analytical charts available.)
Enter TCI Product Number
Enter KISHIDA Product Number
4-5 alphanumeric characters before the hyphen
7 alphanumeric characters
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
• The requested SDS is not available.
Specifications
The requested specifications are not available.
Please Contact Us for more information.
The requested specifications are not available.
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us for more information.
• Please check that the lot number you have entered is correct. It is 7 alphanumeric characters. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
The requested analytical chart is not available. Sorry for the inconvenience.